IP International Journal of Forensic Medicine and Toxicological Sciences
Official Publication of Khyati Education And Research Foundation
Official Publication of Khyati Education And Research Foundation
Print ISSN: 2581-9844
Online ISSN: 2456-9615
CODEN : IIJFA2
IP International Journal of Forensic Medicine and Toxicological Sciences (IJFMTS) open access, peer-reviewed quarterly journal publishing since 2016 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better dissemination of knowledge, we will be more...Case Report
Author Details :
Volume : 9, Issue : 1, Year : 2024
Article Page : 46-52
https://doi.org/10.18231/j.ijfmts.2024.008
Abstract
The local anaesthetic bupivacaine and its metabolites such as Desbutyl bupivacaine, 3-hydroxybupivacaine, and 4-hydroxybupivacaine were extracted and found in the forensic sample from postmortem samples such as cerebrospinal fluid (CSF) and postmortem blood. To separate and detect the aforesaid substances in biological matrices, high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS) and ATR-FTIR methods were used. When a couple of husband and wife who were riding on the side of road by a motor cycle which was abruptly collided by an unknown motor cycle. The couple were injured, especially in the left leg of the lady was severe pain due to bone fracture. Both were immediately admitted in nearby a Government Hospital for treatment. Anaesthetic was injected to the lady before starting the procedure of surgery. Within a few minutes she suffered pulmonary consequence and the mortality immediately occurred. Due to a therapeutic amount of bupivacaine was given, postmortem samples CSF and blood were received at forensic laboratory and extracted using a liquid-liquid extraction method (LLE). Certain chromatographic techniques and ATR-FTIR method were used to separate and detect bupivacaine and its metabolites in a forensic sample.
Keywords: Postmortem blood, CSF, Local anesthetics, HPLC, GCMS, ATRFTIR
How to cite : Gurusamy K, Cyril A, Thangadurai S S, Gupta R R, Local anesthetic marcaine-bupivacaine hydrochloride and its metabolites in Forensic Samples: A case study. IP Int J Forensic Med Toxicol Sci 2024;9(1):46-52
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